The NIMML uses innovation to tackle challenges in infectious, immune-mediated, and chronic inflammatory disease research. We combine computational approaches with pre-clinical and clinical experimentation to transition new biological knowledge into safer and more effective medicines for human diseases.
The Nutritional Immunology and Molecular Medicine Laboratory (NIMML) is a research organization founded in 2002 under the guidance of Dr. Bassaganya-Riera and Dr. Hontecillas. NIMML is committed to a transdisciplinary, team-science approach with a personalized medicine focus at the interface of immunology, inflammation, and nutrition. The NIMML research programs incorporate drug development, nutritional immunology, computational immunology, and translational research in immune mediated, infectious, and chronic inflammatory diseases.
The NIMML research has pioneered pipelines applying high-throughput computational, experimental immunology techniques, and system biology approaches in translational immunology research and discovery. Through the Center for Modeling Immunity to Enteric Pathogens Program, we have applied high performance computing techniques to model and simulate human immunology systems and help immunologists conduct in silico experiments in order to develop a more mechanistic experimental design, validate hypotheses and save significant time and laboratory cost.
NIMML research has received support from the National Institute of Allergy and Infectious Disease at the National Institutes of Health, the National Center for Complementary and Alternative Medicine, Bristol Myers Squibb, Lipid Nutrition, Cognis Nutrition and Health GmbH, BASF, USDA, and commodity groups with a growing research funding portfolio exceeding $15 million.
The MIEP team develops and disseminates user-friendly mathematical and computational models for studying human immunity to infection of vaccination. MIEP combines mathematical modeling and immunology experimentation to characterize the mechanisms of underlying immune responses to enteric pathogens. Models, data, and tools become seamlessly integrated in MIEP’s modeling platform to advance the development of novel host-targeted therapeutics.
The Center for Modeling Immunity to Enteric Pathogens (MIEP) is a NIAID-funded program within the Nutritional Immunology and Molecular Medicine Laboratory. Under the guidance of Dr. Bassaganya-Riera (Principal Investigator), MIEP’s mission is to understand the mechanisms of action underlying immune responses to enteric pathogens.
1. University of Rochester Center for Biodefense Immune Modeling
2. The Center for Computational Immunology
3. The Program for Research on Immune Modeling and Experimentation (PRIME)
4. The Center for Modeling Immunity to Enteric Pathogens (MIEP)
To comprehensively and systematically characterize mechanisms of action underlying infectious, metabolic and immune-mediated diseases; the NIMML will translate this new knowledge towards developing innovative therapeutics for human diseases that are safer and more effective.
To become a world-leading research laboratory in translational, personalized, predictive, participatory, and preventive medicine.
Integrity, creativity, efficiency, teamwork, confidentiality, customer-service orientation, loyalty, commitment, trust, attention to detail, and impeccable work ethics.
"I am really excited about all the research I’ve been doing so far because it allows me to continue working in both experimental and computational studies. Most of the immunologists are not aware of the potential of all the modeling studies going on and how they can speed up experimental achievements."
- Monica Viladomiu
Please contact us if you would like to discuss the possibility of contributing financial support for our research. If you are ready to contribute a tax-deductible donation, please do the following:
- Go to http://www.givingto.vt.edu/MakingAGift/immediate-impact.html and follow the instructions.
- Under the specific area to support, please add: “VBI ref. #871982”
- Under Comments, please include: “For support of Nutritional Immunology and Molecular Medicine Laboratory Research”
Lab Presentation Schedule
|04-14-17||Meghna Verma||Insights on Helicobacter pylori infections using ENISI-MSM|
|03-17-17||Caroline Stewart||Predictive modeling of alternative treatments for C. difficile infection|
|03-03-17||Stefan Weston||LANCL2 Regulation of Akt|
|02-24-17||Mischa Michael||Directed Movement in ENISI-MSM|
|02-17-17||Sara Prince||LANCL2 in Viral Response|
|02-10-17||Ariana Herbst||Data Manipulation and Analysis in Python, R, and MATLAB|
|02-03-17||Nuria Tubau Juni||LANCL2 Regulation of Immunometabolism in IBD|